Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 5/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | HRH2 | P25021 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9426486 | 0.94 | CHRM5 (0.52) | CHRM5CHRM1CHRM4CHRM3CHRM2 | |
| SCHEMBL25973990 | 0.89 | CHRM5 (0.52) | CHRM5CHRM1CHRM4CHRM3CHRM2 | |
| SCHEMBL13652111 | 0.86 | CHRM1 (0.44) | CHRM5CHRM1CHRM4CHRM3CHRM2 | |
| SCHEMBL9426611 | 0.84 | HTR2A (0.42) | CHRM5CHRM1CHRM4CHRM3CHRM2 | |
| SCHEMBL25973998 | 0.82 | CHRM5 (0.55) | CHRM5CHRM1CHRM4CHRM3CHRM2 | |
| SCHEMBL9426661 | 0.80 | TRPM8 (0.46) | DRD2OPRM1ADRB1ADRA2AADRA2B | |
| SCHEMBL9426361 | 0.80 | DRD2 (0.48) | CHRM5CHRM1CHRM4CHRM3CHRM2 | |
| SCHEMBL9426568 | 0.78 | CHRM2 (0.39) | CHRM5CHRM1CHRM4CHRM3CHRM2 | |
| SCHEMBL9426225 | 0.78 | SIGMAR1 (0.48) | CHRM1CHRM3CHRM2KCNH2DRD2 | |
| SCHEMBL8210819 | 0.75 | CHRM5 (0.61) | CHRM5CHRM1CHRM4CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302595-A | Muscarinic receptor antagonists | PFIZER INC. (US) | 1994-04-12 | — | — | US | disclosed |
| US-5219871-A | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1993-06-15 | — | — | US | disclosed |
| EP-0364123-B1 | MUSCARINIC RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 1991-06-12 | — | — | EP | disclosed |
| EP-0364123-A1 | Muscarinic receptor antagonists | Pfizer Limited (GB) | 1990-04-18 | — | — | EP | disclosed |