SCHEMBL9433602

SCHEMBL9433602

O=C(C=Cc1nccc2ccccc12)Cc1cccnc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAPRT Q6XQN6 1/20 0.44
MAPK1 P28482 1/20 0.44
CYP1A2 P05177 5/20 0.43
CYP3A4 P08684 4/20 0.43
CYP1A1 P04798 3/20 0.43
CYP1B1 Q16678 3/20 0.43
CYP2D6 P10635 2/20 0.43
IDO1 P14902 2/20 0.42
NQO2 P16083 1/20 0.41
CYP2C9 P11712 2/20 0.41
POLB P06746 2/20 0.41
CHRNB2 P17787 1/20 0.40
CHRNA7 P36544 1/20 0.40
CHRNA4 P43681 1/20 0.40
CYP2C19 P33261 1/20 0.40
NAMPT P43490 1/20 0.39
ERCC1 P07992 1/20 0.39
ERCC4 Q92889 1/20 0.39
ALDH1A1 P00352 1/20 0.39
S100A4 P26447 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9434607 0.82 CYP1A2 (0.53) NAPRTMAPK1CYP1A2CYP3A4CYP1A1
SCHEMBL9434219 0.78 ALDH1A1 (0.49) NAPRTMAPK1CYP1A2CYP3A4NQO2
SCHEMBL9433797 0.77 NAPRT (0.51) NAPRTCYP1A2CYP3A4CYP2D6IDO1
SCHEMBL9434333 0.76 RAB9A (0.60) NAPRTCYP1A2CYP3A4CYP1A1CYP1B1
SCHEMBL10637111 0.74 NQO2 (0.52) MAPK1CYP1A2CYP3A4CYP1A1CYP1B1
SCHEMBL10637106 0.74 NQO2 (0.52) MAPK1CYP1A2CYP3A4CYP1A1CYP1B1
SCHEMBL9433705 0.74 CYP1A2 (0.46) NAPRTMAPK1CYP1A2CYP3A4CYP1A1
SCHEMBL11547764 0.73 S100A4 (0.44) CYP1A2NQO2CYP2C19S100A4
SCHEMBL9433920 0.73 TBXAS1 (0.56) NAPRTMAPK1CYP1A2CYP3A4CYP1A1
SCHEMBL30843872 0.73 NCOA3 (0.50) MAPK1CYP1A2CYP3A4CYP1A1CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5276150-A Vasodilators, anticoagulants, calcium channel blockers FUJIREBIO INC. (JP) 1994-01-04 US disclosed
EP-0400660-A1 1,4-dihydropyridine derivatives FUJIREBIO INC. (JP) 1990-12-05 EP disclosed