Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.30 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9434368 | 0.71 | SMN1; SMN2 (0.36) | ALDH1A1MAPTCYP1A2NPSR1NPC1 | |
| SCHEMBL9434365 | 0.71 | FGB (0.42) | ALDH1A1MAPTCYP1A2NPC1RAB9A | |
| SCHEMBL8911552 | 0.69 | SMN1; SMN2 (0.36) | ALDH1A1MAPTCYP1A2CYP3A4NPSR1 | |
| SCHEMBL8910142 | 0.66 | GAA (0.33) | ALDH1A1MAPTCYP1A2CYP3A4NPSR1 | |
| SCHEMBL7965432 | 0.65 | MAPT (0.34) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL9435000 | 0.64 | MAPT (0.32) | MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8155848 | 0.61 | PDE1C (0.36) | MAPTMEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL7966334 | 0.61 | KDM4E (0.36) | ALDH1A1MAPTNPSR1RAB9AMEN1 | |
| SCHEMBL7963227 | 0.61 | LMNA (0.36) | ALDH1A1MAPTCYP1A2NPSR1KDM4E | |
| SCHEMBL8536893 | 0.61 | MAPT (0.52) | ALDH1A1MAPTCYP1A2CYP3A4NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |