Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910149 | 0.82 | KMT2A (0.42) | POLBTDP2KMT2A | |
| SCHEMBL8910407 | 0.81 | BCHE (0.39) | KMT2A | |
| SCHEMBL8142537 | 0.73 | MYC (0.34) | KMT2A | |
| SCHEMBL8148024 | 0.71 | TDP2 (0.40) | POLBTDP2KMT2A | |
| SCHEMBL8155023 | 0.69 | HTT (0.33) | KMT2A | |
| SCHEMBL9057850 | 0.68 | MYC (0.36) | — | |
| SCHEMBL8910285 | 0.67 | PARP10 (0.44) | POLBKMT2A | |
| SCHEMBL8909858 | 0.66 | MAPT (0.30) | KMT2A | |
| SCHEMBL8910147 | 0.66 | LMNA (0.31) | — | |
| SCHEMBL8153428 | 0.65 | TP53 (0.36) | POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |