Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437785 | 0.94 | TSHR (0.49) | HSD17B10MAPK1MAPTTSHRTDP1 | |
| SCHEMBL9437836 | 0.88 | MAPT (0.50) | HSD17B10MAPTALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL9437754 | 0.83 | MAPT (0.48) | MAPTALDH1A1KDM4ESIGMAR1MEN1 | |
| SCHEMBL9437778 | 0.78 | SIGMAR1 (0.51) | MAPTSIGMAR1 | |
| SCHEMBL8948178 | 0.76 | SIGMAR1 (0.57) | SIGMAR1 | |
| SCHEMBL9437923 | 0.75 | SIGMAR1 (0.47) | SIGMAR1 | |
| SCHEMBL12691657 | 0.75 | ALDH1A1 (0.63) | HSD17B10MAPK1ALDH1A1SIGMAR1MEN1 | |
| SCHEMBL9437777 | 0.74 | ALDH1A1 (0.42) | HSD17B10MAPK1TSHRTDP1ALDH1A1 | |
| SCHEMBL9437844 | 0.74 | MAPK1 (0.44) | HSD17B10MAPK1TSHRTDP1ALDH1A1 | |
| SCHEMBL9437813 | 0.73 | MAOB (0.47) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5268381-A | Antidepressant or anxiolytic compound | ADIR ET COMPAGNIE (FR) | 1993-12-07 | — | — | US | claimed |
| US-5296477-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5268381-A | Antidepressant or anxiolytic compound | ADIR ET COMPAGNIE (FR) | 1993-12-07 | — | — | US | disclosed |