Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9096619 | 0.87 | ALDH1A1 (0.49) | ALDH1A1CYP3A4CA2TDP1LMNA | |
| SCHEMBL2272799 | 0.86 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CA2TDP1LMNA | |
| Zinc Ion SCHEMBL9440449 | 0.82 | MAPT (0.47) | ALDH1A1CYP3A4CA2TDP1LMNA | |
| SCHEMBL11474832 | 0.80 | MAPT (0.47) | ALDH1A1CYP3A4CA2TDP1LMNA | |
| SCHEMBL9440331 | 0.77 | MAPT (0.45) | ALDH1A1CYP3A4CA2TDP1LMNA | |
| Zinc Ion SCHEMBL9440249 | 0.77 | L3MBTL1 (0.44) | ALDH1A1CA2LMNATSHRHSD17B10 | |
| SCHEMBL1357035 | 0.76 | ALDH1A1 (0.50) | ALDH1A1CYP3A4CA2TDP1LMNA | |
| SCHEMBL1356320 | 0.76 | ALDH1A1 (0.50) | ALDH1A1CYP3A4CA2TDP1LMNA | |
| SCHEMBL4653971 | 0.75 | LMNA (0.49) | ALDH1A1CYP3A4CA2TDP1LMNA | |
| SCHEMBL2850156 | 0.74 | ALDH1A1 (0.52) | ALDH1A1CYP3A4CA2TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433457-B1 | ANTIPRURITIC COMPOSITION | SHISEIDO CO LTD (JP) | 1994-10-19 | — | — | EP | disclosed |
| US-5219847-A | Antipruritic composition | SHISEIDO COMPANY, LTD. (JP) | 1993-06-15 | — | — | US | disclosed |