SCHEMBL944150

SCHEMBL944150

CNC(=O)c1ccc(C=O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 1/20 0.59
HDAC8 Q9BY41 1/20 0.59
HDAC6 Q9UBN7 1/20 0.59
ALDH1A1 P00352 2/20 0.59
HPGD P15428 1/20 0.55
TSHR P16473 1/20 0.55
HTT P42858 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
PLK1 P53350 7/20 0.53
CA2 P00918 1/20 0.50
EPHX2 P34913 1/20 0.50
NR1H4 Q96RI1 1/20 0.50
MMP13 P45452 1/20 0.48
CYP2A6 P11509 1/20 0.44
ALDH5A1 P51649 1/20 0.44
ABAT P80404 1/20 0.44
PARP10 Q53GL7 1/20 0.44
PARP3 Q9Y6F1 1/20 0.44
MKNK1 Q9BUB5 1/20 0.43
MKNK2 Q9HBH9 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24212110 0.94 HDAC6 (0.53) HDAC2HDAC8HDAC6ALDH1A1HPGD
SCHEMBL5391427 0.89 HPGD (0.76) HDAC2HDAC8HDAC6ALDH1A1HPGD
SCHEMBL14358587 0.84 HDAC6 (0.68) HDAC2HDAC8HDAC6ALDH1A1HPGD
SCHEMBL14358593 0.84 HDAC6 (0.68) HDAC2HDAC8HDAC6ALDH1A1HPGD
SCHEMBL7538748 0.83 ALDH1A1 (0.55) HDAC2HDAC8HDAC6ALDH1A1HPGD
SCHEMBL250247 0.83 HDAC6 (0.80) HDAC2HDAC8HDAC6ALDH1A1HPGD
SCHEMBL31482044 0.81 MRGPRX4 (0.56) ALDH1A1HPGDTSHRHTTSMN1; SMN2
SCHEMBL6681528 0.81 HDAC8 (0.57) HDAC2HDAC8HDAC6ALDH1A1HPGD
SCHEMBL15358837 0.80 HDAC1 (0.64) HDAC2HDAC8HDAC6ALDH1A1CA2
SCHEMBL20057794 0.79 BAZ2B (0.68) ALDH1A1SMN1; SMN2MKNK1MKNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11932639-B2 Fused ring heteroaryl compounds as ALK4/5 inhibitors BISICHEM CO., LTD. (KR) 2024-03-19 US disclosed
EP-3892278-B1 CYCLOALKANE-1,3-DIAMINE DERIVATIVE DAIICHI SANKYO CO LTD (JP) 2024-02-28 EP disclosed
WO-2023183628-A9 TARGETED DELIVERY JUDO BIO INC. (US) 2023-11-30 WO disclosed
US-20230303999-A1 COMBINATORIAL PLATFORM FOR HIGH-THROUGHPUT POLYNUCLEOTIDE-ENCODED CATALYST DISCOVERY WISCONSIN ALUMNI RESEARCH FOUNDATION 2023-09-28 US disclosed
WO-2023183628-A2 TARGETED DELIVERY JUDO BIO INC. (US) 2023-09-28 WO disclosed
US-20230273194-A1 NON-INVASIVE METHOD FOR DETECTION OF ENZYME ACTIVITY IN VIVO, SUBSTRATES AND A DEVICE THEREFORE ETH Zürich (CH) 2023-08-31 US disclosed
WO-2023154314-A1 SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-08-17 WO disclosed
US-11702652-B2 Enzymatic encoding methods for efficient synthesis of large libraries NUEVOLUTION A/S (DK) 2023-07-18 US disclosed
US-11560401-B2 Method for preparing oligonucleic acid compound NIPPON SHINYAKU CO., LTD. (JP) 2023-01-24 US disclosed
US-20230014840-A1 METHOD FOR PRODUCING OLIGONUCLEIC ACID COMPOUND NIPPON SHINYAKU CO., LTD. (JP) 2023-01-19 US disclosed
EP-1351928-A2 NOVEL N(PHENYLSULPHONYL)GLYCINE DERIVATIVES AND THEIR THERAPEUTIC USE LABORATOIRES FOURNIER S.A. (FR) 2003-10-15 EP disclosed
WO-2002053516-A2 N(PHENYLSULPHONYL)GLYCINE DERIVATIVES AND THEIR THERAPEUTIC USE LABORATOIRES FOURNIER SA (FR) 2002-07-11 WO disclosed
EP-0622361-B1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 2001-10-04 EP disclosed
US-6169095-B1 FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES IN THE EYE, SUCH AS ALLERGY, INFLAMMATION AND PAIN OF THE EYE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
US-5981533-A INHIBIT THE TYROSINE KINASE ACTIVITY OF THE RECEPTOR FOR EPIDERMAL GROWTH FACTOR AND CAN BE USED IN THE CASE OF EPIDERMAL HYPERPROLIFERATION (PSORIASIS) AND AS ANTI-TUMOR AGENTS NOVARTIS AG (CH) 1999-11-09 US disclosed
US-5922711-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISEASES, SHOCK OR ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-07-13 US disclosed
CN-1043344-C New heterocyclic compounds KRONSEDER MASCHF KRONES (JP) 1999-05-12 CN disclosed
US-5708173-A PREPARATION OF SUBSTITUTED QUINOLINE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-01-13 US disclosed
US-5563162-A CAN BE ADMINISTERD FOR THE TREATMENT OF ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASES, SHOCK OR PAIN IN ANIMALS AND HUMANS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-10-08 US disclosed
EP-0622361-A1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-11-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11932639-B2 Fused ring heteroaryl compounds as ALK4/5 inhibitors ALK, FGFR4, ALKBH3 HDAC2 2463/4885HDAC8 1877/4885HDAC6 2078/4885
US-11560401-B2 Method for preparing oligonucleic acid compound POLRMT, POLI, POLR2H HDAC2 644/4885HDAC8 894/4885HDAC6 1190/4885
US-20230014840-A1 METHOD FOR PRODUCING OLIGONUCLEIC ACID COMPOUND DNASE1, XRN2, FBL HDAC2 742/4885HDAC8 2452/4885HDAC6 2068/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.