Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533769 | 0.67 | SLC6A2 (0.41) | HTR2C | |
| SCHEMBL6753922 | 0.65 | CHRM2 (0.35) | HTR3ACHRM2CHRM1CHRM3 | |
| SCHEMBL3648603 | 0.65 | HTR3A (0.44) | HTR3A | |
| SCHEMBL21193006 | 0.65 | HTR2A (0.40) | HTR3AHTR2AHTR2C | |
| SCHEMBL28533805 | 0.64 | HTR2C (0.57) | HTR2C | |
| SCHEMBL7533765 | 0.64 | HTR3A (0.37) | HTR3A | |
| SCHEMBL4530764 | 0.63 | CHRNB2 (0.47) | HTR2C | |
| SCHEMBL7504353 | 0.63 | HTR2C (0.52) | HTR2C | |
| SCHEMBL31370737 | 0.62 | CHRM2 (0.46) | HTR3AHTR2CCHRM2CHRM1CHRM3 | |
| SCHEMBL3645858 | 0.62 | CHRM2 (0.46) | HTR3AHTR2CCHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260319-A | Analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-09 | — | — | US | disclosed |
| US-5227388-A | Analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-13 | — | — | US | disclosed |
| EP-0435223-A2 | Thienobenzoxepin- and naphthothiophene-derivatives, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-07-03 | — | — | EP | disclosed |
| US-5006536-A | Thienobenzoxepins and analgesic compositions thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-09 | — | — | US | disclosed |