Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629576 | 0.79 | TAAR1 (0.40) | KMT2A | |
| SCHEMBL9447066 | 0.77 | ADRA2B (0.38) | KMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL3962168 | 0.73 | KMT2A (0.49) | COMTKMT2ACYP2A13PDE2ALMNA | |
| SCHEMBL9447121 | 0.71 | MAPT (0.51) | KMT2ALMNAMEN1TP53GAA | |
| SCHEMBL21400926 | 0.70 | KMT2A (0.53) | COMTKMT2ACYP2A13PDE2ALMNA | |
| SCHEMBL954698 | 0.70 | ACHE (0.32) | ACHE | |
| SCHEMBL13293671 | 0.69 | ALDH1A1 (0.54) | COMTKMT2ACYP2A13PDE2ALMNA | |
| Hydrochloric Acid SCHEMBL956803 | 0.69 | ACHE (0.31) | ACHE | |
| SCHEMBL9447022 | 0.69 | HTR1A (0.46) | KMT2AMEN1TP53MAPTMAPK1 | |
| SCHEMBL3278648 | 0.69 | HTR7 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250286-A | Treatment of chronic obstructive pulmonary disease (COPD) by inhalation of an imidazoline | AEGIS TECHNOLOGY, INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0527925-A4 | TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BY INHALATION OF AN IMIDAZOLINE | — | 1993-09-15 | — | — | EP | disclosed |
| EP-0527925-A1 | TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BY INHALATION OF AN IMIDAZOLINE | AEGIS TECHNOLOGIE, INC. (US) | 1993-02-24 | — | — | EP | disclosed |
| US-5096916-A | Administering tolazoline | AEGIS TECHNOLOGY, INC. (US) | 1992-03-17 | — | — | US | disclosed |
| WO-1991016891-A1 | TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BY INHALATION OF AN IMIDAZOLINE | AEGIS TECHNOLOGY, INC. (US) | 1991-11-14 | — | — | WO | disclosed |