Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PTPRF | P10586 | 7/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 7/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9654588 | 0.87 | MAOA (0.48) | MEN1KMT2AGPR35RXFP1GRIN1 | |
| SCHEMBL783749 | 0.80 | NR4A1 (0.50) | GPR35KDM4EGLACA12CA2 | |
| SCHEMBL20793652 | 0.79 | GPR35 (0.51) | MEN1KMT2AGPR35KDM4EGLA | |
| SCHEMBL69699 | 0.78 | NR4A1 (0.54) | GPR35KDM4ECA12CA2CA9 | |
| SCHEMBL9652760 | 0.78 | MAOA (0.54) | KDM4EPIM1 | |
| SCHEMBL18165289 | 0.77 | ALOX5 (0.55) | MEN1KMT2AGPR35RXFP1GRIN1 | |
| SCHEMBL27800011 | 0.77 | MAPT (0.58) | MEN1KMT2AGPR35CA12CA9 | |
| SCHEMBL30829289 | 0.77 | LOXL2 (0.41) | MEN1KMT2AKDM4EPIM1 | |
| SCHEMBL3879946 | 0.77 | LOXL2 (0.41) | MEN1KMT2AKDM4EPIM1 | |
| SCHEMBL23407543 | 0.74 | DYRK1A (0.38) | MEN1KMT2AKDM4EPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5240920-A | 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1993-08-31 | — | — | US | disclosed |
| US-5151512-A | Bactericides | MERCK & CO., INC. (US) | 1992-09-29 | — | — | US | disclosed |
| US-5132420-A | INTERMEDIATES FOR PREPARING 2-(SUBSTITUTED-DIBENZO-FURANYL AND DIBENZOTHIENYL) CARBAPENEM ANTIBACTERIAL AGENTS | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0480715-A1 | Intermediates for preparing 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| EP-0480712-A1 | 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| EP-0405774-A1 | 2-(substituted-dibenzofuranyl and dibenzothienyl)carbapenem antibacterial agents | MERCK & CO. INC. (US) | 1991-01-02 | — | — | EP | disclosed |