Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9451955 | 0.81 | CHRM2 (0.46) | ALDH1A1MAPTKMT2A | |
| SCHEMBL10697680 | 0.81 | DRD2 (0.48) | ALDH1A1MAPTALOX15KMT2ATAAR1 | |
| SCHEMBL9451944 | 0.79 | — | — | |
| SCHEMBL9729439 | 0.78 | MAOA (0.39) | ALDH1A1MAPTKMT2ATAAR1 | |
| SCHEMBL9451907 | 0.78 | RECQL (0.40) | — | |
| SCHEMBL9835542 | 0.78 | MEN1 (0.45) | ALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL10699712 | 0.77 | ALDH1A1 (0.43) | ALDH1A1 | |
| SCHEMBL9833493 | 0.77 | — | — | |
| SCHEMBL9833573 | 0.76 | CHRM1 (0.39) | — | |
| SCHEMBL9728783 | 0.75 | KDM4E (0.46) | ALDH1A1MAPTKMT2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234011-B1 | 4-(1,2,5,6-TETRAHYDRO-1-ALKYL-3-PYRIDINYL)-2-THIAZOLAMINES AND 4-(HEXAHYDRO-1-ALKYL-3-PYRIDINYL)-2-THIAZOLAMINES | WARNER-LAMBERT COMPANY (US) | 1991-09-18 | — | — | EP | claimed |
| EP-0234011-A1 | 4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines | WARNER-LAMBERT COMPANY (US) | 1987-09-02 | — | — | EP | claimed |
| US-RE34242-E | Amino-oxazole compounds having dopaminergic activity | AKZO N.V. (NL) | 1993-05-04 | — | — | US | disclosed |
| EP-0234011-B1 | 4-(1,2,5,6-TETRAHYDRO-1-ALKYL-3-PYRIDINYL)-2-THIAZOLAMINES AND 4-(HEXAHYDRO-1-ALKYL-3-PYRIDINYL)-2-THIAZOLAMINES | WARNER-LAMBERT COMPANY (US) | 1991-09-18 | — | — | EP | disclosed |
| US-4904676-A | DOPAMINE AGONIST; NERVOUS SYSTEM AND CARDIOVASCULAR DISORDERS | AKZO N.V. (NL) | 1990-02-27 | — | — | US | disclosed |
| US-4739067-A | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS, HYPOTENSIVE AGENT, HORMONE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0244018-A1 | Amino-thiazole and oxazole derivatives | AKZO N.V. (NL) | 1987-11-04 | — | — | EP | disclosed |
| EP-0234011-A1 | 4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines | WARNER-LAMBERT COMPANY (US) | 1987-09-02 | — | — | EP | disclosed |
| US-4650805-A | 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity | WARNER-LAMBERT COMPANY (US) | 1987-03-17 | — | — | US | disclosed |