Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 4/20 | 0.31 |
| ▸ | TYMS | P04818 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846309 | 0.92 | FABP4 (0.31) | HCAR2FABP4MEN1ALDH1A1HPGD | |
| SCHEMBL9846072 | 0.90 | TYMS (0.32) | FABP4IDH1TYMSMEN1ALDH1A1 | |
| L-697661 SCHEMBL599639 | 0.86 | FABP4 (0.34) | FABP4IDH1TYMSMEN1ALDH1A1 | |
| L-697661 SCHEMBL29456987 | 0.86 | FABP4 (0.34) | FABP4IDH1TYMSMEN1ALDH1A1 | |
| SCHEMBL9681878 | 0.84 | KMT2A (0.35) | HCAR2MEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL9680329 | 0.83 | PTGES (0.31) | — | |
| SCHEMBL9601892 | 0.82 | ALDH1A1 (0.36) | HCAR2TYMSMEN1ALDH1A1HPGD | |
| SCHEMBL9171193 | 0.79 | FABP4 (0.34) | FABP4IDH1TYMS | |
| SCHEMBL9680865 | 0.78 | NPC1 (0.33) | — | |
| SCHEMBL9846215 | 0.77 | FABP4 (0.31) | FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | claimed |
| US-5200329-A | An Isolating Compound Which is Useful in the Prevention or Tre atment of HIV Infection and the Treatment of AIDS | MERCK & CO., INC. (US) | 1993-04-06 | — | — | US | disclosed |
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |