Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367260 | 0.86 | CES2 (0.47) | L3MBTL1TDP1ALDH1A1LMNAKDM4E | |
| SCHEMBL490151 | 0.82 | ALDH1A1 (0.68) | L3MBTL1TDP1ALDH1A1LMNAKDM4E | |
| SCHEMBL8619264 | 0.81 | CES1 (0.64) | L3MBTL1TDP1ALDH1A1LMNACES2 | |
| SCHEMBL7324968 | 0.79 | ALDH1A1 (0.45) | ALDH1A1LMNAKDM4ECES2CES1 | |
| SCHEMBL9457451 | 0.76 | L3MBTL1 (0.44) | L3MBTL1TDP1ALDH1A1LMNAKDM4E | |
| SCHEMBL11062372 | 0.76 | LMNA (0.59) | L3MBTL1TDP1ALDH1A1LMNAKDM4E | |
| SCHEMBL11067848 | 0.76 | ALDH1A1 (0.44) | L3MBTL1TDP1ALDH1A1LMNAKDM4E | |
| SCHEMBL8620925 | 0.76 | ALDH1A1 (0.61) | L3MBTL1TDP1ALDH1A1KDM4ECES2 | |
| SCHEMBL8617001 | 0.76 | TDP1 (0.58) | L3MBTL1TDP1ALDH1A1CES2CES1 | |
| SCHEMBL2131696 | 0.75 | AKR1B1 (0.62) | L3MBTL1TDP1ALDH1A1LMNACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5225421-A | Leukotriene antagonists; cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1993-07-06 | — | — | US | disclosed |
| EP-0275667-B1 | 3-HETERO-SUBSTITUTED-N-BENZYL-INDOLES | MERCK FROSST CANADA INC. (CA) | 1992-03-18 | — | — | EP | disclosed |
| US-5081138-A | Antiasthmatic, antiallergic, antiinflammatory and cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1992-01-14 | — | — | US | disclosed |
| EP-0275667-A1 | 3-hetero-substituted-N-benzyl-indoles | MERCK FROSST CANADA INC. (CA) | 1988-07-27 | — | — | EP | disclosed |