⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL595653 | 0.97 | — | — | |
| SCHEMBL5393702 | 0.70 | — | — | |
| SCHEMBL8535240 | 0.69 | NOTUM (0.68) | — | |
| SCHEMBL1161426 | 0.65 | — | — | |
| SCHEMBL416800 | 0.65 | MMP1 (0.53) | — | |
| SCHEMBL227129 | 0.65 | — | — | |
| SCHEMBL1843023 | 0.65 | — | — | |
| SCHEMBL8246393 | 0.65 | — | — | |
| SCHEMBL218183 | 0.65 | — | — | |
| SCHEMBL610026 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE34313-E | Neutral 3:1 1-hydroxypyrid-2-one:iron /III/ complexes with specified substituents; treating patients with toxic iron concentrations by administering substituted hydroxypyridnes; use of complexes to increase blood iron levels | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1993-07-13 | — | — | US | claimed |
| EP-0138420-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 1-HYDROXYPYRID-2-ONE DERIVATIVES | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1989-11-29 | — | — | EP | claimed |
| US-4587240-A | ANEMIA, IRON TOXICITY, 1-HYDORXYPYRIDONE-2 | NATIONAL RESEARCH DEVELOPMENT CORP. (GB) | 1986-05-06 | — | — | US | claimed |
| EP-0138420-A2 | Pharmaceutical compositions containing 1-hydroxypyrid-2-one derivatives | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1985-04-24 | — | — | EP | claimed |
| EP-0138420-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 1-HYDROXYPYRID-2-ONE DERIVATIVES | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1989-11-29 | — | — | EP | disclosed |