SCHEMBL416800

SCHEMBL416800

O=C(O)c1cccc(=O)[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 17/20 0.53
MMP12 P39900 17/20 0.53
MMP9 P14780 15/20 0.53
MMP2 P08253 12/20 0.53
KDM4E B2RXH2 1/20 0.46
TDP1 Q9NUW8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17261572 0.80 MMP1 (0.53) MMP1MMP12MMP9MMP2TDP1
SCHEMBL13571768 0.79 MMP1 (0.52) MMP1MMP12MMP9MMP2
SCHEMBL21322002 0.79 MMP1 (0.52) MMP1MMP12MMP9MMP2
SCHEMBL20206904 0.79 MMP1 (0.56) MMP1MMP12MMP9MMP2
SCHEMBL8190893 0.79 MMP1 (0.47) MMP1MMP12MMP9MMP2
SCHEMBL29620349 0.74 MMP2 (0.54) MMP1MMP12MMP9MMP2
SCHEMBL24112333 0.74 MMP1 (0.51) MMP1MMP12MMP9MMP2
SCHEMBL2897889 0.74 MMP1 (0.47) MMP1MMP12MMP9MMP2KDM4E
SCHEMBL1161224 0.74 MMP1 (0.66) MMP1MMP12MMP9MMP2KDM4E
SCHEMBL3724190 0.74 MMP1 (0.51) MMP1MMP12MMP9MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 345 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2635567-B1 INDOLE DERIVATIVES RICHTER GEDEON NYRT (HU) 2015-10-28 EP claimed
US-20130217702-A1 INDOLE DERIVATIVES RICHTER GEDEON NYRT. 2013-08-22 US claimed
CN-103201276-A Indole derivatives RICHTER GEDEON NYRT 2013-07-10 CN claimed
US-20260070896-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS UNIV LEUVEN KATH (BE) 2026-03-12 US disclosed
US-12440584-B2 Macrocyclic ligands with pendant chelating moieties and complexes thereof LUMIPHORE, INC. (US) 2025-10-14 US disclosed
EP-4618755-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2025-09-24 EP disclosed
US-12404266-B2 Heterocycle derivatives for treating TRPM3 mediated disorders KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2025-09-02 US disclosed
CN-115066428-B Boric acid derivatives 首药控股(北京)股份有限公司 2025-06-13 CN disclosed
EP-4554574-A2 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES The Scripps Research Institute (US) 2025-05-21 EP disclosed
CN-119698278-A Small molecule modulators of alveolar type 2 cell proliferation for the treatment of pulmonary diseases 斯克里普斯研究学院 2025-03-25 CN disclosed
CN-119101040-B Method for synthesizing aryl substituted chiral tetrahydropyran ring through desymmetrical synthesis 杭州澳赛诺医药技术有限公司 2025-03-21 CN disclosed
US-7160907-B2 Pleuromutilin derivatives SMITHKLINE BEECHAM P.L.C. (GB) 2007-01-09 US disclosed
US-20060229326-A1 Pyridine-3-carboxamide derivatives as CB1 inverse agonists F. HOFFMANN-LA ROCHE AG (CH) 2006-10-12 US disclosed
WO-2006106054-A1 PYRIDINE-3-CARBOXAMIDE DERIVATIVES AS CB1 INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2006-10-12 WO disclosed
EP-1538150-A1 NOVEL PLEUROMUTILIN DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 2005-06-08 EP disclosed
EP-1351959-B1 NOVEL PLEUROMUTILIN DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 2005-06-01 EP disclosed
US-6900345-B2 Pleuromutilin derivatives SMITHKLINE BEECHAM P.L.C. (GB) 2005-05-31 US disclosed
US-20050096357-A1 Novel pleuromutilin derivatives SMITHKLINE BEECHAM P.L.C. 2005-05-05 US disclosed
EP-1186598-B1 Process of preparing 5-(2-substituted-4-nitrophenyl)-oxazole, oxazole compound, and process of preparing the same NIPPON SYNTHETIC CHEM IND (JP) 2005-03-16 EP disclosed
US-20040024059-A1 Novel pleuromutilin derivatives SMITHKLINE BEECHAM P.L.C. (GB) 2004-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130217702-A1 INDOLE DERIVATIVES BDKRB1, BDKRB2, ARRB1 MMP1 214/4885MMP12 1012/4885MMP9 1011/4885
US-20040024059-A1 Novel pleuromutilin derivatives PLEC, MLNR, FABP2 MMP1 3246/4885MMP12 1619/4885MMP9 2974/4885
US-20060229326-A1 Pyridine-3-carboxamide derivatives as CB1 inverse agonists CNR1, CNR2, GPR119 MMP1 4848/4885MMP12 4489/4885MMP9 4756/4885
US-12440584-B2 Macrocyclic ligands with pendant chelating moieties and complexes thereof TFRC, CLTC, SLC39A3 MMP1 4422/4885MMP12 1086/4885MMP9 3408/4885
US-12404266-B2 Heterocycle derivatives for treating TRPM3 mediated disorders TRPM4, TRPM6, TRPM2 MMP1 4596/4885MMP12 1669/4885MMP9 3044/4885
US-20050096357-A1 Novel pleuromutilin derivatives FABP2, PLEC, MLNR MMP1 3107/4885MMP12 1149/4885MMP9 3139/4885
US-20260070896-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS TRPM6, TRPV3, TRPM2 MMP1 4341/4885MMP12 2416/4885MMP9 2878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.