Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 2/20 | 0.82 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29486822 | 0.90 | AGTR1 (1.00) | AGTR2AGTR1 | |
| SCHEMBL89 | 0.90 | AGTR1 (1.00) | AGTR2AGTR1 | |
| Potassium Ion SCHEMBL9468707 | 0.89 | AGTR1 (0.65) | AGTR2AGTR1 | |
| SCHEMBL9468476 | 0.89 | AGTR1 (0.98) | AGTR2AGTR1 | |
| SCHEMBL9293863 | 0.88 | AGTR2 (0.82) | AGTR2AGTR1 | |
| SCHEMBL462 | 0.87 | AGTR2 (0.80) | AGTR2AGTR1 | |
| SCHEMBL8913274 | 0.87 | AGTR2 (0.65) | AGTR2AGTR1 | |
| SCHEMBL760 | 0.86 | AGTR2 (0.78) | AGTR2AGTR1 | |
| SCHEMBL8913879 | 0.85 | AGTR2 (0.66) | AGTR2AGTR1 | |
| SCHEMBL592 | 0.83 | AGTR2 (1.00) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236943-A | Administering angiotensin II receptor blockers | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-08-17 | — | — | US | disclosed |