Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL9467831 | 0.83 | CA1 (0.52) | CYP1A2ALDH1A1LMNASMN1; SMN2MEN1 | |
| Potassium Ion SCHEMBL6676933 | 0.83 | CA1 (0.52) | CYP1A2CYP3A4ALDH1A1SMN1; SMN2MEN1 | |
| Potassium Ion SCHEMBL1471563 | 0.83 | CA1 (0.52) | CYP1A2ALDH1A1LMNASMN1; SMN2MEN1 | |
| Potassium Ion SCHEMBL1471147 | 0.83 | CA1 (0.52) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| Potassium Ion SCHEMBL1471146 | 0.83 | CA1 (0.52) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| Potassium Ion SCHEMBL6777986 | 0.83 | CA1 (0.52) | CYP1A2CYP3A4ALDH1A1SMN1; SMN2MEN1 | |
| Potassium Ion SCHEMBL1471564 | 0.83 | CA1 (0.52) | CYP1A2ALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL23465057 | 0.82 | ALDH1A1 (0.47) | CYP1A2CYP3A4HIF1AALDH1A1LMNA | |
| SCHEMBL16561212 | 0.82 | ALDH1A1 (0.47) | CYP1A2CYP3A4HIF1AALDH1A1LMNA | |
| Potassium Ion SCHEMBL9468116 | 0.82 | CA2 (0.47) | CYP1A2ALDH1A1LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5206392-A | Reacting arylacetonitriles with glyoxylic acid in presence of base, hydrolyzing, cyclizing | AMERICAN CYANAMID COMPANY (US) | 1993-04-27 | — | — | US | disclosed |