Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | MARK3 | P27448 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838569 | 0.82 | SRC (0.41) | TSHRSRCMYCALDH1A1CCNA2 | |
| SCHEMBL9470368 | 0.78 | ALDH1A1 (0.43) | ALDH1A1HTTNPSR1KMT2A | |
| SCHEMBL9470466 | 0.78 | KMT2A (0.47) | TSHRALDH1A1HTTKMT2A | |
| SCHEMBL9470397 | 0.77 | ADRA2A (0.37) | SRCALDH1A1CCNA2CDK2KMT2A | |
| SCHEMBL9469978 | 0.75 | LMNA (0.40) | TSHRALDH1A1KMT2A | |
| SCHEMBL4690229 | 0.73 | ALDH1A1 (0.34) | ALDH1A1KMT2A | |
| SCHEMBL9469385 | 0.73 | GAA (0.39) | ALDH1A1KMT2A | |
| SCHEMBL9470341 | 0.72 | MEN1 (0.40) | ALDH1A1HTTNPSR1KMT2A | |
| SCHEMBL9469283 | 0.72 | ALDH1A1 (0.39) | TSHRALDH1A1HTTNPSR1KMT2A | |
| SCHEMBL9470503 | 0.71 | ALDH1A1 (0.40) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | claimed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | disclosed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | disclosed |