Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydroxyurea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | ACACB | O00763 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyurea SCHEMBL9474720 | 0.87 | ALOX5 (0.60) | ALOX5NPC1RAB9ASMN1; SMN2LTA4H | |
| SCHEMBL2170633 | 0.79 | ALOX5 (0.67) | ALOX5NPC1RAB9ASMN1; SMN2LTA4H | |
| SCHEMBL28757877 | 0.78 | ALOX5 (0.58) | ALOX5NPC1RAB9ASMN1; SMN2LTA4H | |
| SCHEMBL9685836 | 0.77 | ACACB (0.66) | ALOX5LTA4HACACB | |
| SCHEMBL9474895 | 0.77 | ALOX5 (0.71) | ALOX5NPC1RAB9ASMN1; SMN2LTA4H | |
| SCHEMBL2885897 | 0.76 | ALOX5 (0.62) | ALOX5LTA4HACACB | |
| SCHEMBL9398051 | 0.76 | ACACB (0.60) | ALOX5LTA4HACACB | |
| SCHEMBL8833698 | 0.76 | ALOX5 (0.62) | ALOX5LTA4HACACB | |
| Hydroxyurea SCHEMBL9373841 | 0.76 | FFAR1 (0.58) | LTA4HPARP10 | |
| SCHEMBL9668706 | 0.75 | ALOX5 (0.62) | ALOX5LTA4HACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5185363-A | Administering for treatment of inflammatory diseases | ABBOTT LABORATORIES (US) | 1993-02-09 | — | — | US | disclosed |
| EP-0292699-A2 | Urea based lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1988-11-30 | — | — | EP | disclosed |