Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 13/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9483632 | 0.88 | GABRA3 (0.46) | METAP1KDM4EHTTALDH1A1MAPT | |
| SCHEMBL9476499 | 0.81 | ADRA1A (0.47) | METAP1GRM5KDM4EHTTALDH1A1 | |
| SCHEMBL9476301 | 0.81 | SMO (0.39) | METAP2 | |
| SCHEMBL9476277 | 0.81 | FFAR1 (0.36) | GRM5KDM4EHTTALDH1A1MAPT | |
| SCHEMBL9475729 | 0.80 | KDM4E (0.39) | METAP2METAP1GRM5KDM4EHTT | |
| SCHEMBL9476318 | 0.80 | ABCC9 (0.34) | KDM4EALDH1A1HPGD | |
| SCHEMBL9475857 | 0.78 | KDM4E (0.36) | METAP1KDM4EHTTALDH1A1MAPT | |
| SCHEMBL8332841 | 0.78 | METAP2 (0.40) | METAP2METAP1GRM5KDM4EHTT | |
| SCHEMBL9475451 | 0.78 | CBFB (0.40) | GRM5KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9476263 | 0.78 | KDM4E (0.34) | METAP1KDM4EHTTALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270308-A | Hypotensives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0477789-A1 | 1,3-Benzoxazine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-04-01 | — | — | EP | disclosed |