Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 2/20 | 0.43 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | GPR39 | O43194 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475451 | 0.82 | CBFB (0.40) | CBFBGRM5CHRM1MEN1KMT2A | |
| SCHEMBL8794576 | 0.80 | CBFB (0.43) | CBFBRUNX1GRM5GPR39HCRTR1 | |
| SCHEMBL9476499 | 0.78 | ADRA1A (0.47) | GRM5CHRM1BACE1CTSD | |
| SCHEMBL9475857 | 0.78 | KDM4E (0.36) | CHRM1KMT2A | |
| SCHEMBL9475729 | 0.77 | KDM4E (0.39) | GRM5CHRM1 | |
| SCHEMBL9478570 | 0.77 | GPR3 (0.33) | CHRM1GPR3CES1BACE1ABL1 | |
| SCHEMBL8874508 | 0.77 | CBFB (0.41) | CBFBRUNX1GRM5GPR39HCRTR1 | |
| SCHEMBL9475576 | 0.76 | GRM5 (0.42) | GRM5KMT2A | |
| SCHEMBL27344045 | 0.76 | TP53 (0.33) | BACE1CTSD | |
| SCHEMBL9476263 | 0.75 | KDM4E (0.34) | BACE1MEN1KMT2ACTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1060467-A | 1,3-benzoxazine derivatives, its production method and purposes | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1992-04-22 | — | — | CN | claimed |
| US-5270308-A | Hypotensives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-12-14 | — | — | US | disclosed |
| CN-1060467-A | 1,3-benzoxazine derivatives, its production method and purposes | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1992-04-22 | — | — | CN | disclosed |
| EP-0477789-A1 | 1,3-Benzoxazine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-04-01 | — | — | EP | disclosed |