Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476195 | 0.85 | ADORA3 (0.51) | KMT2AMEN1HPGDPOLBRAD51 | |
| SCHEMBL9475856 | 0.85 | HPGD (0.59) | GRM2KMT2AMEN1HPGDPOLB | |
| SCHEMBL9477367 | 0.81 | ADORA3 (0.46) | KMT2AMEN1HPGDMAPTTSHR | |
| SCHEMBL14094136 | 0.80 | POLB (0.43) | KMT2AMEN1HPGDPOLBRAD51 | |
| SCHEMBL9476624 | 0.78 | TSHR (0.61) | GRM2KMT2AMEN1HPGDPOLB | |
| SCHEMBL9476484 | 0.75 | GRM2 (0.53) | GRM2KMT2AMEN1HPGDPOLB | |
| SCHEMBL30931879 | 0.74 | PDE8B (0.53) | KMT2AMEN1HPGDTSHRALOX15 | |
| SCHEMBL9476371 | 0.72 | LMNA (0.53) | KMT2AMEN1HPGDTSHRTP53 | |
| SCHEMBL9476477 | 0.72 | MEN1 (0.62) | KMT2AMEN1HPGDTSHRTP53 | |
| SCHEMBL9478099 | 0.72 | ALDH1A1 (0.56) | GRM2HPGDMAPTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204353-A | 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith | CIBA-GEIGY CORPORATION (US) | 1993-04-20 | — | — | US | disclosed |
| EP-0288431-B1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1992-08-19 | — | — | EP | disclosed |
| EP-0288431-A1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1988-10-26 | — | — | EP | disclosed |