Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9479014 | 0.74 | ALDH1A1 (0.40) | MAPTPOLBLMNATP53HPGD | |
| SCHEMBL9179794 | 0.71 | GRM2 (0.43) | MAPTTP53GRM2HSD17B10HTT | |
| SCHEMBL13120839 | 0.70 | ALDH1A1 (0.41) | MAPTHPGDHSD17B10HTT | |
| SCHEMBL9184025 | 0.70 | CASP3 (0.44) | POLBLMNATP53RAB9AGRM2 | |
| SCHEMBL7444401 | 0.69 | ALDH1A1 (0.47) | MAPTPOLB | |
| SCHEMBL10429061 | 0.64 | KDM4E (0.50) | POLBLMNAHPGDRAB9A | |
| SCHEMBL924028 | 0.64 | TSHR (0.54) | MAPTPOLBHPGDHSD17B10HTT | |
| SCHEMBL3186789 | 0.64 | MAPK14 (0.49) | MAPTPOLBLMNATP53HPGD | |
| SCHEMBL13635755 | 0.63 | ALDH1A1 (0.56) | MAPTPOLBLMNAHPGDGRM2 | |
| SCHEMBL5313911 | 0.63 | LMNA (0.46) | MAPTPOLBLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5242928-A | Angiotensin II antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-09-07 | — | — | US | disclosed |
| EP-0547514-A2 | Imidazopyridine derivatives with angiotensin-II antagonist properties | MERCK PATENT GmbH (DE) | 1993-06-23 | — | — | EP | disclosed |