Ethyl Acetate

Ethyl Acetate

SCHEMBL948368

CCO.CCOC(C)=O.CCOC(C)=O

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Ethyl Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.88
LMNA P02545 1/20 0.88
HSD17B10 Q99714 1/20 0.88
TSHR P16473 1/20 0.52
GAA P10253 2/20 0.48
ALOX15 P16050 1/20 0.48
MGAM O43451 1/20 0.48
SI P14410 1/20 0.48
MGAM2 Q2M2H8 1/20 0.48
SOAT1 P35610 1/20 0.48
TRPA1 O75762 1/20 0.43
GLO1 Q04760 1/20 0.42
KDM4E B2RXH2 1/20 0.41
PKM P14618 1/20 0.41
CA12 O43570 2/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA9 Q16790 2/20 0.41
CHRM5 P08912 2/20 0.40
CHRM1 P11229 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethyl Acetate SCHEMBL8096789 1.00 ALDH1A1 (0.88) ALDH1A1LMNAHSD17B10TSHRGAA
Ethyl Acetate SCHEMBL8145547 1.00 ALDH1A1 (0.88) ALDH1A1LMNAHSD17B10TSHRGAA
Ethyl Acetate SCHEMBL11473005 1.00 ALDH1A1 (0.88) ALDH1A1LMNAHSD17B10TSHRGAA
Ethyl Acetate SCHEMBL1816268 1.00 ALDH1A1 (0.88) ALDH1A1LMNAHSD17B10TSHRGAA
Ethyl Acetate SCHEMBL15443206 1.00 ALDH1A1 (0.88) ALDH1A1LMNAHSD17B10TSHRGAA
Ethyl Acetate SCHEMBL6066779 1.00 ALDH1A1 (0.88) ALDH1A1LMNAHSD17B10TSHRGAA
Ethyl Acetate SCHEMBL18492853 1.00 ALDH1A1 (0.88) ALDH1A1LMNAHSD17B10TSHRGAA
Ethyl Acetate SCHEMBL15546159 1.00 ALDH1A1 (0.88) ALDH1A1LMNAHSD17B10TSHRGAA
Ethyl Acetate SCHEMBL2309223 1.00 ALDH1A1 (0.88) ALDH1A1LMNAHSD17B10TSHRGAA
Ethyl Acetate SCHEMBL15546699 1.00 ALDH1A1 (0.88) ALDH1A1LMNAHSD17B10TSHRGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110021636-A1 METHOD FOR CRYSTALLIZATION OF 2-AMINO-2-[2-[4-(3-BENZYLOXYPHENYLTHIO)-2-CHLOROPHENYL]-ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-01-27 US claimed
EP-2269982-A1 METHOD FOR CRYSTALLIZATION OF 2-AMINO-2-Ý2-Ý4-(3- BENZYLOXYPHENYLTHIO)-2-CHLOROPHENYL¨ETHYL¨-1,3-PROPANEDIOL HYDROCHLORIDE Kyorin Pharmaceutical Co., Ltd. (JP) 2011-01-05 EP claimed
EP-3565817-B1 SMALL MOLECULE INHIBITORS OF NEUTRAL SPHINGOMYELINASE 2 (NSMASE2) FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES UNIV JOHNS HOPKINS (US) 2023-06-07 EP disclosed
US-20200190089-A1 SMALL MOLECULE INHIBITORS OF NEUTRAL SPHINGOMYELINASE 2 (NSMASE2) FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR V.V.I. (CZ) 2020-06-18 US disclosed
EP-3565817-A1 SMALL MOLECULE INHIBITORS OF NEUTRAL SPHINGOMYELINASE 2 (nSMase2) FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES The Johns Hopkins University (US) 2019-11-13 EP disclosed
US-20190038604-A1 BICYCLIC COMPOUND, PRODUCTION AND USE THEREOF TOBIRA THERAPEUTICS, INC. (US) 2019-02-07 US disclosed
WO-2018129405-A1 SMALL MOLECULE INHIBITORS OF NEUTRAL SPHINGOMYELINASE 2 (nSMase2) FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES THE JOHNS HOPKINS UNIVERSITY (US) 2018-07-12 WO disclosed
US-9603833-B2 Benzene or thiophene derivative and use thereof as VAP-1 inhibitor R-TECH UENO, LTD. (JP) 2017-03-28 US disclosed
US-20160008326-A1 BICYCLIC COMPOUND, PRODUCTION AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-01-14 US disclosed
EP-1556389-B9 CEPHEM COMPOUNDS ASTELLAS PHARMA INC (JP) 2015-09-09 EP disclosed
EP-2886534-A1 Benzene or thiophene derivative and use thereof as VAP-1 inhibitor R-Tech Ueno, Ltd. (JP) 2015-06-24 EP disclosed
US-6172061-B1 AIDS THERAPY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed
US-6166006-A Anilide derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-12-26 US disclosed
EP-1040103-A1 ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-10-04 EP disclosed
EP-1039899-A2 PHARMACEUTICAL COMPOSITION FOR ANTAGONIZING CCR5 COMPRISING ANILIDE DERIVATIVE Takeda Chemical Industries, Ltd. (JP) 2000-10-04 EP disclosed
WO-2000037455-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-06-29 WO disclosed
WO-1999032100-A2 PHARMACEUTICAL COMPOSITION FOR ANTAGONIZING CCR5 COMPRISING ANILIDE DERIVATIVE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-07-01 WO disclosed
WO-1999032468-A1 ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-07-01 WO disclosed
CN-1176785-A Tricyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-03-25 CN disclosed
US-4400470-A SYNERGISTIC EFFECT OF CLOSTRIDIUM THERMOCELLUM AND THERMOHYDROSULFURICUM WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1983-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160008326-A1 BICYCLIC COMPOUND, PRODUCTION AND USE THEREOF CCR5, CCR1, CCR2 ALDH1A1 2749/4885LMNA 4328/4885HSD17B10 2514/4885
US-20110021636-A1 METHOD FOR CRYSTALLIZATION OF 2-AMINO-2-[2-[4-(3-BENZYLOXYPHENYLTHIO)-2-CHLOROPHENYL]-ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE PKD2, PKD1, AASDHPPT ALDH1A1 526/4885LMNA 2382/4885HSD17B10 196/4885
US-20190038604-A1 BICYCLIC COMPOUND, PRODUCTION AND USE THEREOF CCR5, CCR1, CCR2 ALDH1A1 2749/4885LMNA 4285/4885HSD17B10 2532/4885
US-20200190089-A1 SMALL MOLECULE INHIBITORS OF NEUTRAL SPHINGOMYELINASE 2 (NSMASE2) FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES SMPD2, SPTLC2, SGMS2 ALDH1A1 4149/4885LMNA 2641/4885HSD17B10 1760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.