SCHEMBL9489355

SCHEMBL9489355

F[B-](F)(F)F.N#[N+]c1ccc(F)cc1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.39
CES1 P23141 3/20 0.39
ALDH1A1 P00352 2/20 0.38
CA3 P07451 1/20 0.33
CA6 P23280 1/20 0.33
CA5A P35218 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
CA5B Q9Y2D0 1/20 0.33
ATM Q13315 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
USP2 O75604 1/20 0.32
DHFR P00374 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
LMNA P02545 1/20 0.32
TTR P02766 1/20 0.32
ALB P02768 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30816696 0.93 ALDH1A1 (0.42) CES2CES1ALDH1A1CA3CA6
SCHEMBL11862205 0.93 ALDH1A1 (0.42) CES2CES1ALDH1A1CA3CA6
SCHEMBL4062591 0.83 CES2 (0.39) CES2CES1ALDH1A1CA3CA6
SCHEMBL29094042 0.79 ACHE (0.31)
SCHEMBL11486407 0.79 HPGD (0.33) HPGD
SCHEMBL9844828 0.79 CCR2 (0.32) HPGDKMT2A
SCHEMBL4060558 0.75 HPGD (0.30) HPGD
Trichloroacetic Acid SCHEMBL11864292 0.75 CES2 (0.38) CES2CES1ALDH1A1ATMTDP1
SCHEMBL5182959 0.75 CA3 (0.42) CES2CES1ALDH1A1CA3CA6
SCHEMBL8849876 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0525019-A1 PROCESS FOR PREPARATION OF 1,2,4-TRIFLUOROBENZENE AND 1-CHLORO-3,4-DIFLUOROBENZENE PFIZER INC. (US) 1993-02-03 EP claimed
WO-1991016287-A1 PROCESS FOR PREPARATION OF 1,2,4-TRIFLUOROBENZENE AND 1-CHLORO-3,4-DIFLUOROBENZENE PFIZER INC. (US) 1991-10-31 WO claimed
US-3992459-A BIARYL COUPLING BY DIAZOTIZATION MERCK & CO., INC. (US) 1976-11-16 US claimed
EP-4594311-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES Syngenta Crop Protection AG (CH) 2025-08-06 EP disclosed
WO-2024068947-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-04-04 WO disclosed
EP-0458823-B1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1993-10-13 EP disclosed
US-5245039-A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA (IT) 1993-09-14 US disclosed
EP-0525019-A1 PROCESS FOR PREPARATION OF 1,2,4-TRIFLUOROBENZENE AND 1-CHLORO-3,4-DIFLUOROBENZENE PFIZER INC. (US) 1993-02-03 EP disclosed
EP-0525019-A1 PROCESS FOR PREPARATION OF 1,2,4-TRIFLUOROBENZENE AND 1-CHLORO-3,4-DIFLUOROBENZENE PFIZER INC. (US) 1993-02-03 EP disclosed
EP-0458823-A1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES. BOEHRINGER MANNHEIM ITALIA (IT) 1991-12-04 EP disclosed
WO-1991016287-A1 PROCESS FOR PREPARATION OF 1,2,4-TRIFLUOROBENZENE AND 1-CHLORO-3,4-DIFLUOROBENZENE PFIZER INC. (US) 1991-10-31 WO disclosed
WO-1991016287-A1 PROCESS FOR PREPARATION OF 1,2,4-TRIFLUOROBENZENE AND 1-CHLORO-3,4-DIFLUOROBENZENE PFIZER INC. (US) 1991-10-31 WO disclosed
WO-1990009376-A1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1990-08-23 WO disclosed
EP-0383320-A1 A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1990-08-22 EP disclosed
US-4847442-A Process for the preparation of difluorobenzenes ALLIED-SIGNAL INC. (US) 1989-07-11 US disclosed
US-4216340-A Preparation of 5-(2,4-difluorophenyl)salicylic acid and derivatives MERCK & CO., INC. (US) 1980-08-05 US disclosed
US-3992459-A BIARYL COUPLING BY DIAZOTIZATION MERCK & CO., INC. (US) 1976-11-16 US disclosed