Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.66 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.52 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14830351 | 0.88 | HIF1A (0.81) | HIF1AKDM4CNOX4FOLH1ALDH1A1 | |
| SCHEMBL27648140 | 0.79 | ALDH1A1 (0.49) | HIF1AKDM4CKDM4EKDM6BKDM4A | |
| SCHEMBL3168102 | 0.79 | CHRNB2 (0.49) | HIF1AKDM4CNOX4KDM4EKDM6B | |
| SCHEMBL9567555 | 0.76 | HPGD (0.63) | HIF1AKDM4CKDM4EKDM6BKDM4A | |
| SCHEMBL30879601 | 0.75 | HIF1A (0.57) | HIF1AKDM4EFOLH1ALDH1A1GAA | |
| SCHEMBL17737239 | 0.75 | TSHR (0.67) | HIF1AKDM6BFOLH1ALDH1A1GAA | |
| SCHEMBL6119714 | 0.74 | HIF1A (0.61) | HIF1AKDM4CNOX4ALDH1A1HTT | |
| SCHEMBL28741561 | 0.74 | HIF1A (0.61) | HIF1ANOX4KDM4EALDH1A1 | |
| SCHEMBL29373730 | 0.73 | KDR (0.57) | KDM4CKDM4EKDM6BFOLH1ALDH1A1 | |
| SCHEMBL6779496 | 0.73 | FFAR1 (0.55) | ALDH1A1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | claimed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | claimed |
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |
| US-4309541-A | CHEMICAL INTERMEDIATES TO QUINAZOLINE HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |
| US-4255429-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| US-4000287-A | HYPOTENSIVES, ANTIARRHYTHMIC | CIBA-GEIGY CORPORATION (US) | 1976-12-28 | — | — | US | disclosed |