SCHEMBL9499094

SCHEMBL9499094

O=C(Cl)C(=O)c1cc[c]cc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.40
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18554639 0.80 ALDH1A1 (0.41) CES2LMNAGAA
SCHEMBL17977304 0.79 CES2 (0.34) CES2LMNAGAA
SCHEMBL1896544 0.79 KIF11 (0.36) CES2LMNAGAA
SCHEMBL21268411 0.75 CFTR (0.44) CES2LMNA
SCHEMBL8163828 0.71 CES2 (0.31) CES2
SCHEMBL1510099 0.70 FFAR1 (0.32) LMNA
SCHEMBL146460 0.68 AR (0.31) GAA
SCHEMBL103466 0.67 IDO1 (0.35)
SCHEMBL717093 0.67 HSD17B1 (0.33)
SCHEMBL14483362 0.66 GLA (0.38) GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0322788-B1 MELT-PROCESSABLE AROMATIC POLYESTERAMIDES HAVING REPEATING 2,2'-SUBSTITUTED BIPHENYLENE RADICALS POLAROID CORPORATION (US) 1993-04-28 EP disclosed
EP-0322788-A2 Melt-processable aromatic polyesteramides having repeating 2,2'-substituted biphenylene radicals POLAROID CORPORATION (US) 1989-07-05 EP disclosed
EP-0322787-A2 Melt-processable polyesteramides having para-linked, substituted phenylene radicals POLAROID CORPORATION (US) 1989-07-05 EP disclosed
US-4843141-A HIGH STREENGTH FILMS AND FIBERS POLAROID CORPORATION, PATENT DEPARTMENT (US) 1989-06-27 US disclosed
US-4792597-A Melt-processable polyesteramides having para-linked, substituted-phenylene radicals POLAROID CORPORATION (US) 1988-12-20 US disclosed
US-4608429-A Low-melting aromatic polyesters with repeating 2,2'-substituted-biphenylene radicals POLAROID CORPORATION, PATENT DEPT. (US) 1986-08-26 US disclosed
US-4575547-A MELT PROCESSABILITY AND ANISOTROPY POLAROID CORPORATION (US) 1986-03-11 US disclosed