Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502196 | 0.88 | CYP2D6 (0.47) | LMNAKMT2AALDH1A1MEN1GAA | |
| SCHEMBL9504119 | 0.84 | CYP2D6 (0.44) | TSHRLMNAUSP2KMT2AALDH1A1 | |
| SCHEMBL9501107 | 0.74 | TSHR (0.48) | GPBAR1TSHRHSD17B10LMNAUSP2 | |
| SCHEMBL9502829 | 0.74 | SIGMAR1 (0.41) | LMNAALDH1A1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL10518201 | 0.70 | CXCR4 (0.46) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3830421 | 0.70 | GPBAR1 (0.90) | GPBAR1TSHRHSD17B10LMNAUSP2 | |
| SCHEMBL4184681 | 0.70 | GPBAR1 (0.90) | GPBAR1TSHRHSD17B10LMNAUSP2 | |
| SCHEMBL31350913 | 0.69 | RXFP1 (0.71) | GPBAR1TSHRHSD17B10LMNAUSP2 | |
| SCHEMBL9502149 | 0.68 | TSHR (0.48) | GPBAR1TSHRHSD17B10LMNAUSP2 | |
| SCHEMBL9502634 | 0.68 | LMNA (0.49) | TSHRHSD17B10LMNAUSP2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | claimed |
| US-4960883-A | Cardiovascular disorders | KOWA COMPANY, LTD. (JP) | 1990-10-02 | — | — | US | claimed |
| EP-0330910-A1 | Propane derivatives | KOWA COMPANY, LTD. (JP) | 1989-09-06 | — | — | EP | claimed |
| JP-1207276-A | — | — | None | — | — | JP | disclosed |
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | disclosed |
| US-4960883-A | Cardiovascular disorders | KOWA COMPANY, LTD. (JP) | 1990-10-02 | — | — | US | disclosed |
| EP-0330910-A1 | Propane derivatives | KOWA COMPANY, LTD. (JP) | 1989-09-06 | — | — | EP | disclosed |
| JP-H01207276-A | NOVEL PROPANE DERIVATIVE | KOWA CO | 1989-08-21 | — | — | JP | disclosed |