Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502196 | 0.96 | CYP2D6 (0.47) | CYP2D6ALDH1A1POLBKDM4EKMT2A | |
| SCHEMBL9502763 | 0.86 | FABP6 (0.43) | CYP2D6ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL9502157 | 0.84 | GPBAR1 (0.47) | ALDH1A1POLBKDM4ETSHRUSP2 | |
| SCHEMBL10518201 | 0.78 | CXCR4 (0.46) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9502829 | 0.77 | SIGMAR1 (0.41) | ALDH1A1POLBKDM4ELMNASMN1; SMN2 | |
| SCHEMBL10386225 | 0.75 | ALDH1A1 (0.45) | CYP2D6ALDH1A1POLBKDM4EUSP2 | |
| SCHEMBL9502634 | 0.73 | LMNA (0.49) | CYP2D6ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL9504097 | 0.73 | KDM4E (0.45) | CYP2D6ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL12726868 | 0.72 | CYP2D6 (0.76) | CYP2D6ALDH1A1POLBTSHRUSP2 | |
| SCHEMBL9501073 | 0.69 | GAA (0.59) | CYP2D6ALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | claimed |
| US-4960883-A | Cardiovascular disorders | KOWA COMPANY, LTD. (JP) | 1990-10-02 | — | — | US | claimed |
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | disclosed |
| US-4960883-A | Cardiovascular disorders | KOWA COMPANY, LTD. (JP) | 1990-10-02 | — | — | US | disclosed |
| EP-0330910-A1 | Propane derivatives | KOWA COMPANY, LTD. (JP) | 1989-09-06 | — | — | EP | disclosed |