Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10518201 | 0.96 | CXCR4 (0.46) | SIGMAR1CXCR4SLC6A4SLC6A2SMN1; SMN2 | |
| SCHEMBL9502763 | 0.82 | FABP6 (0.43) | SMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL9502196 | 0.80 | CYP2D6 (0.47) | SMN1; SMN2POLBKDM4EALDH1A1LMNA | |
| SCHEMBL9504119 | 0.77 | CYP2D6 (0.44) | SMN1; SMN2POLBKDM4EALDH1A1LMNA | |
| SCHEMBL10316558 | 0.74 | SIGMAR1 (0.50) | SIGMAR1CXCR4SLC6A4SLC6A2SMN1; SMN2 | |
| SCHEMBL9502157 | 0.74 | GPBAR1 (0.47) | SMN1; SMN2POLBKDM4EALDH1A1LMNA | |
| SCHEMBL10986097 | 0.73 | SIGMAR1 (0.50) | SIGMAR1SLC6A4SLC6A2SMN1; SMN2POLB | |
| SCHEMBL9048459 | 0.72 | SLC6A4 (0.50) | SIGMAR1CXCR4SLC6A4SLC6A2POLB | |
| SCHEMBL11099406 | 0.71 | SLC6A4 (0.54) | SIGMAR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11166093 | 0.68 | SIGMAR1 (0.56) | SIGMAR1SLC6A4SLC6A2LTA4HLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | claimed |
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | disclosed |
| US-4960883-A | Cardiovascular disorders | KOWA COMPANY, LTD. (JP) | 1990-10-02 | — | — | US | disclosed |
| EP-0330910-A1 | Propane derivatives | KOWA COMPANY, LTD. (JP) | 1989-09-06 | — | — | EP | disclosed |