Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | HTR3A | P46098 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504429 | 0.88 | MEN1 (0.38) | KMT2AGAAMEN1LMNANOTUM | |
| SCHEMBL9501160 | 0.85 | LMNA (0.36) | KMT2AGAAMEN1LMNAALDH1A1 | |
| SCHEMBL9501084 | 0.85 | MEN1 (0.42) | KMT2AGAAMEN1LMNANOTUM | |
| SCHEMBL10501494 | 0.84 | KMT2A (0.36) | KMT2AGAAMEN1NOTUMPKM | |
| SCHEMBL9500884 | 0.78 | MEN1 (0.37) | KMT2AGAAMEN1LMNANOTUM | |
| SCHEMBL10733171 | 0.74 | HTR1A (0.36) | KMT2AMEN1CYP1A2CYP3A4HTR1A | |
| SCHEMBL9504425 | 0.71 | NPBWR1 (0.35) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7919150 | 0.70 | TSHR (0.38) | KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL10502467 | 0.67 | NPC1 (0.40) | LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2033033 | 0.67 | CYP3A4 (0.47) | KMT2AMAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154885-B1 | SUBSTITUTED 2-PHENYL-HEXAHYDRO-1,2,4-TRIAZINE-2,5-DIONES, METHOD FOR THEIR PREPARATION, THEIR USE AS VETERINARY MEDICINES AND FOR COMBATING PROTOZOES | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-18 | — | — | EP | claimed |
| US-5188832-A | Triazine-dione compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-23 | — | — | US | disclosed |