Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.35 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504013 | 0.83 | KDM4E (0.40) | KDM4ECYP2D6KMT2AMEN1 | |
| SCHEMBL9502192 | 0.81 | TDP1 (0.43) | LMNAKDM4ECYP2D6KMT2AMEN1 | |
| SCHEMBL9502822 | 0.76 | LMNA (0.50) | SLC6A4SLC6A2LMNAKDM4ESLC6A3 | |
| SCHEMBL9501470 | 0.76 | KDM4E (0.38) | LMNAKDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9502149 | 0.75 | TSHR (0.48) | LMNAKDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10518194 | 0.73 | LMNA (0.46) | SLC6A4SLC6A2LMNAKDM4ESLC6A3 | |
| SCHEMBL8635727 | 0.69 | CHRM2 (0.54) | LMNAKDM4E | |
| SCHEMBL593284 | 0.63 | LMNA (0.96) | SLC6A4SLC6A2LMNAKDM4EKMT2A | |
| SCHEMBL8750527 | 0.63 | TACR1 (0.42) | SLC6A4SLC6A2LMNAKDM4EKCNH2 | |
| SCHEMBL607717 | 0.62 | ADRA2C (0.58) | LMNAKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | disclosed |
| US-4960883-A | Cardiovascular disorders | KOWA COMPANY, LTD. (JP) | 1990-10-02 | — | — | US | disclosed |