Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9507066 | 0.90 | TAS1R3 (0.35) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9503470 | 0.84 | CA1 (0.40) | CA1CA2MTNR1AMTNR1BKDM4E | |
| SCHEMBL9504412 | 0.74 | TAS1R3 (0.38) | TAS1R3TAS1R1TAS1R2KDM4ELMNA | |
| SCHEMBL9503511 | 0.67 | TAS1R3 (0.41) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9503507 | 0.66 | TAS1R3 (0.43) | TAS1R3TAS1R1TAS1R2CA1CA2 | |
| SCHEMBL9505387 | 0.63 | ADRA2A (0.60) | — | |
| Hydrochloric Acid SCHEMBL9507138 | 0.62 | ADRA2A (0.59) | — | |
| SCHEMBL704770 | 0.61 | TAS1R3 (1.00) | TAS1R3TAS1R1TAS1R2TDP1CA1 | |
| SCHEMBL17236386 | 0.60 | CA1 (0.52) | TAS1R3TAS1R1TAS1R2CA1CA2 | |
| SCHEMBL8888088 | 0.59 | MTNR1A (0.66) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321968-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5151414-A | Hypotensive agents | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-09-29 | — | — | US | disclosed |
| US-5070106-A | HYPOTENSIVES, CEREBRAL DISORDERS | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1991-12-03 | — | — | US | disclosed |
| EP-0321968-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |