Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 8/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 8/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 8/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.32 |
| ▸ | DRD5 | P21918 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9507066 | 0.76 | TAS1R3 (0.35) | TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL9503495 | 0.74 | TAS1R3 (0.43) | TAS1R3TAS1R1TAS1R2KDM4ELMNA | |
| SCHEMBL9504633 | 0.67 | PTGER4 (0.37) | ALDH1A1KMT2A | |
| SCHEMBL9507191 | 0.67 | TAS1R3 (0.36) | TAS1R3TAS1R1TAS1R2IGF1RALOX15 | |
| SCHEMBL9504418 | 0.66 | HTR6 (0.38) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9504423 | 0.65 | NPC1 (0.38) | TAS1R3TAS1R1TAS1R2KDM4EALDH1A1 | |
| SCHEMBL9504432 | 0.63 | ADRA2A (0.44) | IGF1RALOX15KDM4E | |
| Succinic Acid SCHEMBL9505506 | 0.62 | ADRA2A (0.39) | TAS1R3TAS1R1TAS1R2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9503363 | 0.62 | ADRA2A (0.43) | IGF1RALOX15KDM4E | |
| SCHEMBL9503722 | 0.60 | ADRA2A (0.43) | KDM4EDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321968-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5151414-A | Hypotensive agents | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-09-29 | — | — | US | disclosed |
| US-5070106-A | HYPOTENSIVES, CEREBRAL DISORDERS | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1991-12-03 | — | — | US | disclosed |
| EP-0321968-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |