Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.60 |
| ▸ | THRA | P10827 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | SCN1A | P35498 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | HRH2 | P25021 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336224 | 0.89 | THRA (0.58) | THRBTHRAHRH2HRH1 | |
| SCHEMBL7331718 | 0.80 | HTR1A (0.64) | THRBTHRAALDH1A1LMNAMAPT | |
| SCHEMBL9505612 | 0.78 | THRB (0.63) | THRBTHRAALDH1A1LMNAMAPT | |
| SCHEMBL25887676 | 0.76 | THRA (0.57) | THRBTHRAHDAC1TSHR | |
| SCHEMBL7335005 | 0.76 | THRB (0.54) | THRBTHRAALDH1A1LMNAMAPT | |
| SCHEMBL7337997 | 0.76 | THRB (0.54) | THRBTHRAALDH1A1LMNAMAPT | |
| SCHEMBL863522 | 0.76 | SMN1; SMN2 (0.81) | THRBTHRAALDH1A1LMNAMAPT | |
| SCHEMBL11222638 | 0.76 | THRB (0.97) | THRBTHRAALDH1A1LMNAMAPT | |
| SCHEMBL7329573 | 0.76 | MCHR1 (0.56) | THRBTHRASIGMAR1 | |
| Pramoxine SCHEMBL26020 | 0.75 | ALDH1A1 (1.00) | THRBTHRAALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552309-A1 | NEW PROCESS FOR BIOPHOSPHORYLATING ORGANIC COMPOUNDS | MERCK & CO. INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| WO-1992006992-A2 | NEW PROCESS FOR BIOPHOSPHORYLATING ORGANIC COMPOUNDS | MERCK & CO., INC. (US) | 1992-04-30 | — | — | WO | disclosed |