Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | EBP | Q15125 | 1/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504591 | 0.94 | SIGMAR1 (0.59) | SIGMAR1EBPTMEM97 | |
| Fumaric Acid SCHEMBL9506530 | 0.76 | SIGMAR1 (0.35) | SIGMAR1EBPTMEM97 | |
| SCHEMBL9503522 | 0.75 | SIGMAR1 (0.52) | SIGMAR1EBPTMEM97 | |
| Oxalic Acid SCHEMBL8728738 | 0.74 | SIGMAR1 (0.89) | SIGMAR1EBPTMEM97 | |
| Oxalic Acid SCHEMBL8201207 | 0.74 | SIGMAR1 (0.80) | SIGMAR1EBPTMEM97 | |
| SCHEMBL9504487 | 0.74 | ADRA1D (0.74) | SIGMAR1EBPTMEM97 | |
| Oxalic Acid SCHEMBL8198623 | 0.74 | SIGMAR1 (0.79) | SIGMAR1EBPTMEM97 | |
| Hydrochloric Acid SCHEMBL9505511 | 0.73 | ADRA1D (0.73) | SIGMAR1EBPTMEM97 | |
| Oxalic Acid SCHEMBL9077112 | 0.73 | SIGMAR1 (0.78) | SIGMAR1EBPTMEM97 | |
| SCHEMBL3228699 | 0.73 | SIGMAR1 (1.00) | SIGMAR1EBPTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321967-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| EP-0321967-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |