Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | EBP | Q15125 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9504595 | 0.95 | SIGMAR1 (0.36) | SIGMAR1EBPTMEM97ALDH1A1NPBWR1 | |
| Maleic Acid SCHEMBL9506523 | 0.76 | SIGMAR1 (0.56) | SIGMAR1EBPTMEM97 | |
| SCHEMBL9504591 | 0.70 | SIGMAR1 (0.59) | SIGMAR1EBPTMEM97 | |
| SCHEMBL9503527 | 0.69 | BCHE (0.40) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL9503329 | 0.65 | KDM4E (0.36) | ALDH1A1NPBWR1SMN1; SMN2MCHR1 | |
| Hydrochloric Acid SCHEMBL30961584 | 0.65 | ALDH1A1 (0.59) | SIGMAR1EBPTMEM97ALDH1A1 | |
| SCHEMBL9505422 | 0.64 | BCHE (0.36) | — | |
| SCHEMBL9503554 | 0.61 | NPC1 (0.35) | SMN1; SMN2 | |
| SCHEMBL9504487 | 0.59 | ADRA1D (0.74) | SIGMAR1EBPTMEM97 | |
| Hydrochloric Acid SCHEMBL9505511 | 0.59 | ADRA1D (0.73) | SIGMAR1EBPTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321967-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| EP-0321967-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |