Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9509595 | 0.85 | GAA (0.41) | GAAKMT2AMEN1ALDH1A1FABP3 | |
| SCHEMBL9510979 | 0.74 | MMP1 (0.42) | GAAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL9508531 | 0.72 | SLC6A4 (0.51) | ALDH1A1SLC6A4SLC6A2SLC6A3APP | |
| SCHEMBL9507496 | 0.71 | HTR7 (0.46) | KMT2AMEN1ALDH1A1SLC6A4SLC6A2 | |
| SCHEMBL9509583 | 0.68 | SLC6A4 (0.44) | KMT2AMEN1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9507325 | 0.68 | MAOB (0.42) | KMT2AMEN1ALDH1A1SLC6A4SLC6A2 | |
| SCHEMBL10705108 | 0.67 | GAA (0.58) | GAAKMT2AMEN1ALDH1A1MAOB | |
| SCHEMBL12831776 | 0.67 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL30716088 | 0.65 | TP53 (0.46) | GAAKMT2AMEN1FABP3FABP4 | |
| SCHEMBL31075610 | 0.65 | FABP3 (0.43) | FABP3FABP4APPMAOBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358305-B1 | MERCAPTO-PHENYLALCANOYLAMINO ACID AMIDES, THEIR PREPARATION AND THEIR USE AS COLLAGENASE INHIBITORS | BEECHAM GROUP PLC (GB) | 1993-08-25 | — | — | EP | disclosed |
| US-5124322-A | Antiarthritic agents | BEECHAM GROUP P.L.C. (GB) | 1992-06-23 | — | — | US | disclosed |
| EP-0358305-A1 | Mercapto-phenylalcanoylamino acid amides, their preparation and their use as collagenase inhibitors | BEECHAM GROUP PLC (GB) | 1990-03-14 | — | — | EP | disclosed |