Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | ANPEP | P15144 | 3/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900045 | 0.81 | HTR2A (0.38) | SIGMAR1HTR2ARETPLAUHTR2C | |
| SCHEMBL30779196 | 0.78 | CA2 (0.40) | SIGMAR1PLAUANPEPHTR6 | |
| SCHEMBL8368477 | 0.76 | SIGMAR1 (0.42) | SIGMAR1 | |
| SCHEMBL7587595 | 0.75 | SIGMAR1 (0.38) | SIGMAR1GRIN2B | |
| SCHEMBL6676676 | 0.75 | PLAU (0.45) | SIGMAR1HTR2APLAUIDO1ANPEP | |
| SCHEMBL5255259 | 0.75 | PLAU (0.45) | SIGMAR1HTR2APLAUIDO1ANPEP | |
| Formamide SCHEMBL9730102 | 0.74 | SIGMAR1 (0.35) | SIGMAR1 | |
| SCHEMBL9730098 | 0.74 | ALOX5 (0.40) | SIGMAR1 | |
| SCHEMBL8702582 | 0.74 | SIGMAR1 (0.37) | SIGMAR1 | |
| SCHEMBL9508490 | 0.73 | MEN1 (0.33) | HTR2ARETHTR2CHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140039-A | Antidepressants, metabolic disorders | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |