SCHEMBL9510017

SCHEMBL9510017

COS(=O)(=O)c1cc2c(cc1Cl)Sc1cc(S(=O)(=O)OC)c(Cl)cc1S2

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CTPS1 P17812 1/20 0.33
TSHR P16473 2/20 0.30
POLB P06746 1/20 0.30
GLA P06280 1/20 0.30
TRPV4 Q9HBA0 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16467792 0.79 L3MBTL1 (0.44) CTPS1TSHRPOLBGLATRPV4
SCHEMBL9511270 0.78 L3MBTL1 (0.35) ALDH1A1
SCHEMBL9510093 0.75 TRPV4 (0.41) TRPV4
SCHEMBL9507595 0.75 TRPV4 (0.41) TRPV4
SCHEMBL16467798 0.73 SMN1; SMN2 (0.40) POLB
SCHEMBL13290923 0.71 TRPV4 (0.50) TSHRPOLBTRPV4ALDH1A1
SCHEMBL5318058 0.71 ALDH1A1 (0.49) TSHRPOLBTRPV4ALDH1A1
SCHEMBL9950188 0.69 TRPV4 (0.38) TSHRPOLBTRPV4ALDH1A1
SCHEMBL9507618 0.68 GAA (0.48) POLBALDH1A1
SCHEMBL15353058 0.68 KDM4E (0.42) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0399293-B1 PROCESS FOR PREPARING 2-CHLORO-4-NITRO-ALKYLBENZENE BAYER AG (DE) 1993-09-01 EP disclosed
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed
EP-0399293-A1 Process for preparing 2-chloro-4-nitro-alkylbenzene BAYER AG (DE) 1990-11-28 EP disclosed