Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9512288 | 0.89 | KMT2A (0.49) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL9511108 | 0.87 | KMT2A (0.48) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL27747982 | 0.76 | ALDH1A1 (0.44) | CYP2D6KCNH2ALDH1A1LMNACYP3A4 | |
| SCHEMBL9511082 | 0.72 | HTR7 (0.67) | HTR2ADRD3ALDH1A1LMNAHTT | |
| SCHEMBL7977689 | 0.71 | OPRM1 (0.78) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL3919536 | 0.71 | OPRM1 (0.78) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL8186671 | 0.71 | OPRM1 (0.78) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL8175607 | 0.71 | OPRM1 (0.78) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL26192614 | 0.71 | OPRM1 (0.61) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL9512269 | 0.70 | HTR7 (0.60) | HTR2ADRD3ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330065-B1 | Sulfonamide compounds | KOWA CO (JP) | 1993-11-10 | — | — | EP | claimed |
| US-4948892-A | Sulfonamid compound useful for treating cardiovascular disorders | KOWA COMP., LTD. (JP) | 1990-08-14 | — | — | US | claimed |
| EP-0330065-A1 | Sulfonamide compounds | KOWA COMPANY, LTD. (JP) | 1989-08-30 | — | — | EP | claimed |
| JP-1211567-A | — | — | None | — | — | JP | disclosed |
| EP-0330065-B1 | Sulfonamide compounds | KOWA CO (JP) | 1993-11-10 | — | — | EP | disclosed |
| US-4948892-A | Sulfonamid compound useful for treating cardiovascular disorders | KOWA COMP., LTD. (JP) | 1990-08-14 | — | — | US | disclosed |
| JP-H01211567-A | NOVEL SULFONAMIDE COMPOUND | KOWA CO | 1989-08-24 | — | — | JP | disclosed |