Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513807 | 0.93 | MEN1 (0.38) | MEN1KMT2ALMNATP53MAPT | |
| SCHEMBL9513786 | 0.88 | NPC1 (0.48) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9514704 | 0.87 | NPC1 (0.47) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9516240 | 0.85 | NPC1 (0.48) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9516852 | 0.84 | MAPT (0.40) | RAB9AMEN1KMT2ALMNATP53 | |
| SCHEMBL9514774 | 0.80 | HTR1A (0.42) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL9515163 | 0.80 | STAT3 (0.40) | NPC1RAB9AMAPTTDP1ALDH1A1 | |
| SCHEMBL9514280 | 0.77 | HTR1A (0.44) | — | |
| SCHEMBL9514297 | 0.73 | HTR1A (0.39) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL9516233 | 0.71 | ALDH1A1 (0.42) | MEN1KMT2ALMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227488-A | AZA SPIRO DECANE AND USE THEREOF IN TREATING CNS DISORDERS | NOVO NORDISK A/S (DK) | 1993-07-13 | — | — | US | disclosed |
| EP-0495826-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-29 | — | — | EP | disclosed |
| WO-1991004973-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-04-18 | — | — | WO | disclosed |