Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513786 | 0.99 | NPC1 (0.48) | NPC1RAB9AALDH1A1KMT2ASTAT3 | |
| SCHEMBL9516240 | 0.96 | NPC1 (0.48) | NPC1RAB9AALDH1A1KMT2ASTAT3 | |
| SCHEMBL9515163 | 0.92 | STAT3 (0.40) | NPC1RAB9AALDH1A1STAT3HTR1A | |
| SCHEMBL9513586 | 0.87 | NPC1 (0.37) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL9517210 | 0.82 | MAPT (0.42) | ALDH1A1STAT3HTR1A | |
| SCHEMBL9513807 | 0.79 | MEN1 (0.38) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL9517046 | 0.78 | MAPT (0.54) | NPC1RAB9AKMT2ASTAT3HTR1A | |
| SCHEMBL9517236 | 0.76 | HTR1A (0.43) | ALDH1A1STAT3HTR1A | |
| SCHEMBL9513686 | 0.75 | SIGMAR1 (0.47) | STAT3HTR1A | |
| SCHEMBL9603353 | 0.75 | HTR2A (0.48) | NPC1RAB9AALDH1A1KMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0495826-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-29 | — | — | EP | claimed |
| WO-1991004973-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-04-18 | — | — | WO | claimed |
| US-5227488-A | AZA SPIRO DECANE AND USE THEREOF IN TREATING CNS DISORDERS | NOVO NORDISK A/S (DK) | 1993-07-13 | — | — | US | disclosed |
| EP-0495826-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-29 | — | — | EP | disclosed |
| WO-1991004973-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-04-18 | — | — | WO | disclosed |