Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513786 | 0.92 | NPC1 (0.48) | STAT3NPC1RAB9AHTR1AALDH1A1 | |
| SCHEMBL9514704 | 0.92 | NPC1 (0.47) | STAT3NPC1RAB9AHTR1AALDH1A1 | |
| SCHEMBL9516240 | 0.89 | NPC1 (0.48) | STAT3NPC1RAB9AHTR1AALDH1A1 | |
| SCHEMBL9513807 | 0.87 | MEN1 (0.38) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9517210 | 0.84 | MAPT (0.42) | STAT3HTR1AMAPTTDP1GFER | |
| SCHEMBL9603353 | 0.82 | HTR2A (0.48) | NPC1RAB9AHTR1AMAPTTDP1 | |
| SCHEMBL9517046 | 0.82 | MAPT (0.54) | STAT3NPC1RAB9AHTR1AMAPT | |
| SCHEMBL9513586 | 0.80 | NPC1 (0.37) | NPC1RAB9AMAPTTDP1ALDH1A1 | |
| SCHEMBL9517236 | 0.78 | HTR1A (0.43) | STAT3HTR1AMAPTTDP1GFER | |
| SCHEMBL9513686 | 0.77 | SIGMAR1 (0.47) | STAT3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227488-A | AZA SPIRO DECANE AND USE THEREOF IN TREATING CNS DISORDERS | NOVO NORDISK A/S (DK) | 1993-07-13 | — | — | US | disclosed |
| EP-0495826-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-29 | — | — | EP | disclosed |
| WO-1991004973-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-04-18 | — | — | WO | disclosed |