Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.61 |
| ▸ | HTR1A | P08908 | 5/20 | 0.61 |
| ▸ | HTR2C | P28335 | 4/20 | 0.61 |
| ▸ | HTR1B | P28222 | 4/20 | 0.61 |
| ▸ | HTR1D | P28221 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 1/20 | 0.61 |
| ▸ | HTR6 | P50406 | 1/20 | 0.61 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.61 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 4/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3563693 | 0.83 | HTR6 (0.63) | HTR2AHTR1AHTR2CHTR1BHTR1D | |
| SCHEMBL28337310 | 0.81 | GPR84 (0.64) | HTR2AHTR1AHTR2CHTR1BHTR1D | |
| SCHEMBL4489769 | 0.76 | NR4A2 (0.57) | HTR1ACYP1A2MAPTHTR2BBLM | |
| 5-Methoxytryptamine SCHEMBL41982 | 0.76 | HTR1A (1.00) | HTR2AHTR1AHTR2CHTR1BHTR1D | |
| 5-Methoxytryptamine SCHEMBL29390103 | 0.76 | HTR1A (1.00) | HTR2AHTR1AHTR2CHTR1BHTR1D | |
| SCHEMBL3976318 | 0.75 | HTR2B (1.00) | HTR2AHTR1AHTR2CHTR1BHTR1D | |
| 5-Methoxytryptamine SCHEMBL130877 | 0.75 | HTR1A (0.97) | HTR2AHTR1AHTR2CHTR1BHTR1D | |
| 5-Methoxytryptamine SCHEMBL1322980 | 0.75 | NPSR1 (1.00) | HTR2AHTR1AHTR2CHTR1BHTR1D | |
| 5-Methoxytryptamine SCHEMBL31109114 | 0.75 | NPSR1 (1.00) | HTR2AHTR1AHTR2CHTR1BHTR1D | |
| 5-Methoxytryptamine SCHEMBL26617456 | 0.75 | HTR1A (0.97) | HTR2AHTR1AHTR2CHTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227488-A | AZA SPIRO DECANE AND USE THEREOF IN TREATING CNS DISORDERS | NOVO NORDISK A/S (DK) | 1993-07-13 | — | — | US | disclosed |
| EP-0495826-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-29 | — | — | EP | disclosed |
| WO-1991004973-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-04-18 | — | — | WO | disclosed |