Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18534068 | 0.82 | TSHR (0.33) | TSHRNFKB1CYP2C19APLNR | |
| SCHEMBL27392295 | 0.79 | THRA (0.35) | THRATHRB | |
| SCHEMBL12110903 | 0.74 | APLNR (0.58) | TSHRNFKB1CYP2C19APLNR | |
| SCHEMBL6676053 | 0.73 | SMN1; SMN2 (0.38) | TSHRNFKB1CYP2C19APLNR | |
| SCHEMBL6464880 | 0.73 | THRA (0.39) | THRATHRBAPLNR | |
| SCHEMBL10807653 | 0.73 | ALDH1A1 (0.39) | — | |
| SCHEMBL68608 | 0.72 | TSHR (0.43) | THRBTSHRCYP2C19 | |
| SCHEMBL5401959 | 0.72 | TSHR (0.32) | TSHRNFKB1CYP2C19APLNR | |
| SCHEMBL68637 | 0.72 | HDAC4 (0.36) | TSHR | |
| SCHEMBL69507 | 0.72 | TSHR (0.33) | TSHRNFKB1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307041-B1 | Sterically hindered amino compounds and processes for their preparation | ENIRICERCHE SPA (IT) | 1993-12-15 | — | — | EP | disclosed |
| US-5135986-A | Graft polymers of styrene or A-methylstyrene and a comonomer on a core of elastomer modified by a steric hindered unsaturated 2,2,6,6-tetramethylpiperidine compoune; photostability | CIBA-GEIGY CORPORATION (US) | 1992-08-04 | — | — | US | disclosed |
| US-4980477-A | POLYMER STABILIZERS; PHOTOSTABILITY TO UV RAD | ENIRICERCHE SPA (IT) | 1990-12-25 | — | — | US | disclosed |
| EP-0307041-A2 | Sterically hindered amino compounds and processes for their preparation | ENIRICERCHE S.p.A. (IT) | 1989-03-15 | — | — | EP | disclosed |