Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.51 |
| ▸ | CXCR2 | P25025 | 12/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 9/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566833 | 0.89 | P4HTM (0.63) | P4HTMCXCR2CXCR1PTPN1PTPN6 | |
| SCHEMBL9519528 | 0.86 | RAB9A (0.58) | P4HTMCXCR2CXCR1ALDH1A1KMT2A | |
| SCHEMBL9515480 | 0.85 | CXCR2 (0.52) | P4HTMCXCR2CXCR1ALDH1A1KMT2A | |
| SCHEMBL9519474 | 0.83 | CXCR2 (0.50) | P4HTMCXCR2CXCR1ALDH1A1KMT2A | |
| SCHEMBL9566852 | 0.82 | P4HTM (0.55) | P4HTMCXCR2CXCR1PTPN1PTPN6 | |
| SCHEMBL9519589 | 0.81 | CXCR2 (0.54) | P4HTMCXCR2CXCR1KMT2AMEN1 | |
| SCHEMBL9519350 | 0.76 | CXCR2 (0.43) | P4HTMCXCR2CXCR1KMT2AMEN1 | |
| SCHEMBL12444447 | 0.76 | L3MBTL1 (0.57) | ALDH1A1KMT2ACYP3A4MEN1 | |
| SCHEMBL9517022 | 0.75 | — | — | |
| SCHEMBL9566835 | 0.75 | P4HTM (0.63) | P4HTMALDH1A1KMT2AKCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |