Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.55 |
| ▸ | CXCR2 | P25025 | 10/20 | 0.54 |
| ▸ | CXCR1 | P25024 | 8/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.52 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.52 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.52 |
| ▸ | F13A1 | P00488 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566833 | 0.92 | P4HTM (0.63) | P4HTMCXCR2CXCR1PTPN1PTPN6 | |
| SCHEMBL9566811 | 0.87 | CXCR2 (0.57) | P4HTMCXCR2CXCR1F2PLG | |
| SCHEMBL9566753 | 0.85 | CXCR2 (0.54) | P4HTMCXCR2CXCR1F2PLG | |
| SCHEMBL9566883 | 0.85 | CXCR2 (0.52) | P4HTMCXCR2CXCR1F2PLG | |
| SCHEMBL9566803 | 0.83 | P4HTM (0.66) | P4HTMALDH1A1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL9566799 | 0.82 | CXCR2 (0.53) | P4HTMCXCR2CXCR1KMT2AKCNQ3 | |
| SCHEMBL9566829 | 0.82 | CXCR2 (0.58) | P4HTMCXCR2CXCR1HDAC1KMT2A | |
| SCHEMBL9566887 | 0.82 | P4HTM (0.69) | P4HTMALDH1A1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL9517015 | 0.82 | P4HTM (0.51) | P4HTMCXCR2CXCR1PTPN1PTPN6 | |
| SCHEMBL9566862 | 0.81 | ABL1 (0.51) | P4HTMKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533130-A1 | 2-Hydroxymethylpyridines, the corresponding pyridine-N-oxides and derivatives thereof, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |