Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 5/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.38 |
| ▸ | CASP3 | P42574 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515607 | 0.88 | EPHX2 (0.40) | CXCR2CXCR1EPHX2CASP3CYP2C9 | |
| SCHEMBL9517908 | 0.85 | CXCR1 (0.39) | CXCR2CXCR1EPHX2CASP3CYP2C9 | |
| SCHEMBL9518019 | 0.83 | MEN1 (0.39) | CXCR2CXCR1EPHX2CASP3KMT2A | |
| SCHEMBL9517093 | 0.82 | P4HTM (0.39) | CXCR2CXCR1EPHX2KMT2ACYP2C9 | |
| SCHEMBL9517229 | 0.80 | POLB (0.38) | CXCR2CXCR1CASP3P4HTMMAPT | |
| SCHEMBL9519643 | 0.79 | GRM5 (0.39) | CXCR2CXCR1CASP3P4HTM | |
| SCHEMBL9517259 | 0.78 | EGFR (0.39) | EPHX2CASP3P4HTM | |
| SCHEMBL9517222 | 0.78 | TRPM8 (0.38) | EPHX2CASP3P4HTM | |
| SCHEMBL9515729 | 0.78 | BCL2L1 (0.40) | CXCR2CASP3KMT2ABCL2L1MCL1 | |
| SCHEMBL9516087 | 0.78 | BCL2L1 (0.38) | CXCR2EPHX2CASP3BCL2L1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |