Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 3/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519643 | 0.87 | GRM5 (0.39) | GRM5CASP3GABRA5HDAC6CXCR1 | |
| SCHEMBL9516262 | 0.85 | GRM5 (0.40) | GRM5CASP3GABRA5LMNAHDAC6 | |
| SCHEMBL9517233 | 0.85 | POLB (0.38) | POLBSMN1; SMN2TDP1GRM5L3MBTL1 | |
| SCHEMBL9517025 | 0.82 | CASP3 (0.39) | GRM5L3MBTL1RAB9ACASP3HDAC6 | |
| SCHEMBL9517088 | 0.80 | CXCR2 (0.38) | CASP3MAPTCXCR1CXCR2P4HTM | |
| SCHEMBL9517994 | 0.78 | P4HTM (0.49) | POLBSMN1; SMN2L3MBTL1KDM4EGAA | |
| SCHEMBL9519634 | 0.77 | HDAC1 (0.39) | CASP3HDAC6 | |
| SCHEMBL9515607 | 0.77 | EPHX2 (0.40) | CASP3GABRA5HDAC6CXCR1CXCR2 | |
| SCHEMBL9515933 | 0.75 | P4HTM (0.55) | L3MBTL1KDM4EGAACASP3TP53 | |
| SCHEMBL9519391 | 0.74 | HDAC6 (0.38) | CASP3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |